AB0633 Health-Related Quality of Life in ANCA Vasculitides and Rheumatoid Arthritis patients: a cross-sectional comparative study

Background ANCA associated vasculitides (AAVs) are rare, serious forms of vasculitides. There limited data regarding the quality life in patients with AAVs compared to other chronic inflammatory diseases. Objectives The purpose this study was compare between AAV and those a arthritis such as rheumatoid (RA). Methods Multicenter, cross-sectional RA followed three tertiary referral centers. Data from 1007 healthy controls served historic controls. 1 HRQoL assessed Short Form 36 Health Survey (SF-36) which includes physical mental component summary scores (PCS MCS). Disease activity were Birmingham Vasculitis Activity Score version 3 (BVAS 3, for AAVs) DAS28-ESR (for RA) respectively organ damage/function Damage Index (VDI score Assessment Questionnaire (HAQ scores, respectively. Results 66 (GPA 62%, MPA 29% EGPA 9%, females 56%, mean age 63.4 years, generalized disease 74%, duration 6.2 remission 73%) 71 (females 63.3 72%) included. Both had significantly lower PCS MCS (p < 0.05) while 0.05). According status, there no difference SF-36 active > 1) inactive AAV, except energy-fatigue (55.0 ± 21.8 vs. 67.2 20.7, p= 0.038) whereas (DAS28-ESR 3.2) all SF36 components low 3.2). Additionally, both increased damage 3) less 3), (33.9 10.1 49.1 10.2, p 0.001) damage/poor functionality ≥ 0.75) ≤ 0.63), (35.0 7.2 48.4 8.6, (40.5 8.6 48.2 7.6, 0.001 respectively). Compared pain (37.7 28.6 61.2 29.5, 0.024). Conclusion In general, RA, demonstrate impaired group, correlated more patients, damage. These emphasize need efficacious therapies that could prevent improve life. References [1]Pappa, E., Kontodimopoulos, N. & Niakas, D. Validating norming Greek Survey. Qual Life Res 14, 1433–1438 (2005). Acknowledgements Supported part by Rheumatology Society Professional Association Rheumatologists (ERE-EPERE) Special Account Research Grants (S.A.R.G.), National Kapodistrian University Athens, Greece (DV #12085, 12086). Disclosure Interests None declared